Research Paper
SYNTHESIS OF TRIFLUOROMETHYL, CONTAINING 1-(3,5- DIALKYL-4-HYDROXYBENZYL) -PYRAZOLE AND PYRAZOL-5- ONE DERIVATIVES, AS POTENTIAL FUNGICIDES
Author: AMRENDRA KUMAR SINGH*, AND NITIN SINGH SOLUNKEY**,
*Department Of Applied Chemistry [U.N.S.,Inst.,of Engg. & Tech.] V.B.S. Purvanchal University Jaunpur (U.P.)India. e-Mail:aks.vbspu@gmail.com
**Department Of Applied Chemistry [U.N.S.,Inst.,of Engg. & Tech.] V.B.S. Purvanchal University Jaunpur (U.P.)India
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Abstract
3,5-Dialkyl-4-hydroxybenzylhydrazine(1) reacted with hexafluoroacetylacetone, and trifluoroacetylacetone yielding the pyrazoles (2) bearing trifluoromethyl and/or methyl substituents in positions 3 and 5. The same hydrazine derivatives (1) afforded the pyrazol-5-ones (3) with trifluoroacetoacetic acid ethyl ester. The synthesized compounds have been screened against P.oryzae & H. oryze.
Keywords:
fluorination, pyrazole, pyrazolone, trifluoromethyl-1,3-diketones.
