Research Paper
Synthesis, Characterization, Antimicrobial and Antifungal Activity Of Pyrazolene-Benzofuran
Author: KHAGESH KUMAR SINGH, ,
(ASSOCIATE PROFESSOR) SHRI RAM MURTI SMARAK COLLEGE OF ENGG.& TECH. BAREILLY, 243001
e-mail khagesh_10@sify.com khageshsingh2010@yahoo.com (Mob. 09837325726)
Address for correspondence: 336 Beharipur Civil Lines ,Bareilly (UP)
{published research paper}
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Abstract
Benzofuran
compounds are ubiquitous in nature, particularly among plant kingdom. Often such natural products possessing benzofuran nucleus are endowed with useful pharmacological properties. This has generated enormous interest in synthetic products containing benzofuran nucleus and has resulted in the development of benzofuran chemistry during the last several years. The recent reviews of literature shows that benzofuran was clinically potent moiety possess diverse biological activities and profound efficacy. Among the wide variety of Nitrogen heterocyclic compounds that have been exploited to develop pharmaceutically important molecule such as Pyrazole and their derivatives due to their diverse biological activities such as Anti-inflammatory, Antifungal, Anti-bacterial, Anti-Pyretic and others. Pyrazole derivatives have a long history of application in agrochemicals and pharmaceutical industry as herbicides and active pharmaceuticals. The recent success of pyrazole COX-2 inhibitor has further highlighted the importance of these heterocycles in medicinal chemistry. A Systematic investigation of this class of heterocyclic lead revealed that pyrazole containing pharmacoactive agents play important role in medicinal chemistry. The prevalence of pyrazole cores in biologically active molecules has stimulated the need for elegant and efficient ways to make these heterocyclic lead.
