Research Paper
SYNTHESIS OF BENZIMIDOLYL CHALCONES INTO N1– SSUBSTITUTED PYRAZOLINES AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITIES.
Author: NITIN SINGH SOLUNKEY*, AND AMRENDRA KUMAR SINGH**,
*Department Of Applied Chemistry [U.N.S.,Inst.,of Engg. & Tech.] V.B.S. Purvanchal University Jaunpur (U.P.)India.
**Department Of Applied Chemistry [U.N.S.,Inst.,of Engg. & Tech.] V.B.S. Purvanchal University Jaunpur (U.P.)India. e-Mail:aks.vbspu@gmail.com
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Abstract
1-Benzimidazolyl-3-aryl-prop-2-cne-1-ones (2) have been synthsised into N1-substiluted pyrazoline derivatives by the vinteraction with phenyl hydrazine, thiosemicarbazide and hydraine hydrate in the presence of formic acid.The structure of newly synthesized compounds have been confirmed on the basis of their eiemntal analysis and spectral data. Newly synthesized compounds have been evaluated for their antimicrobial-activity in vitro against E. coil, P. aerugiiwsa and fungus P.oryzae, H.oryzae using paper disc method. Some of the compounds have shown significant activity against the pathogens.
Keywords :
Benzimidolyl, pyrazolines, antimicrobial.
